The Arizona Cardinals will look to stay perfect in Week 5 as they host the San Francisco 49ers, who have dropped two straight after opening the season 2-0. The 4-0 Cards could be facing rookie QB Trey Lance, as Jimmy Garoppolo is dealing with a leg injury but has yet to be ruled out.
The Cardinals are 7-3 SU in the last 10 meetings, with each team splitting a pair of road games last season. Arizona is a 5-point home favorite with the total set at 50 on the NFL betting board.
Here are our free picks and predictions for 49ers vs. Cardinals for Sunday, October 10.
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